Dr. William Clearfield

PRP Joint Project

Platelet-Rich Plasma (PRP) therapy is transforming the way we treat joint degeneration, particularly in conditions like knee osteoarthritis. By using your body’s own growth factors, PRP promotes healing, reduces inflammation, and may even slow cartilage breakdown—offering a natural alternative to surgery or long-term medication.

Treatment Protocol

Our standard PRP protocol for joint therapy includes:

  • Two PRP injections administered 28 days apart
  • A third injection is rarely needed, but may be considered in resistant cases

We do not use local anesthetics during the procedure. Research shows that local anesthetics can:

  • Be toxic to chondrocytes (cartilage-producing cells)
  • Alter the pH balance, which can interfere with platelet activation and reduce the efficacy of PRP therapy (1)

How PRP Works

PRP is derived from your own blood, concentrated with platelets that contain powerful healing proteins and growth factors. When injected into an injured joint:

  • It stimulates tissue repair
  • Reduces inflammation
  • Enhancesjoint lubrication
  • May support cartilage regeneration
PRP

PRP vs. Hyaluronic Acid: Which Is Better?

A one-year randomized clinical trial published in Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders (2015) by Raeissadat et al. compared PRP with hyaluronic acid (HA) for knee osteoarthritis. Results showed:

TreatmentPain ReliefFunction ImprovementDuration of Effectiveness
PRPSignificantGreater than HASustained up to 12 months
HAModerateLess than PRPWanes after 3–6 months

The study concluded that PRP offered superior and longer-lasting relief compared to hyaluronic acid, making it a promising first-line treatment for degenerative joint conditions.

Learn More About PRP for Joint and Musculoskeletal Conditions

Explore additional resources and studies on PRP therapy:

References:

The study by Raeissadat et al. (2015), published in Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, examined the different injection options for knee osteoarthritis, specifically comparing platelet-rich plasma (PRP) and hyaluronic acid.

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